Anti Ageing Bi Effect
Cardiolipin-The role of ischemic heart disease and Parkinson's
Cardiolipin-The role of ischemic heart disease and Parkinson's
Cardiolipin or 1,3 precisely - a (sn -3 '-phosphatidyl) - sn-glycerol is a very important part of the mitochondria. It is a phoshlipid with a dimeric structure, having four acyl groups and potentially carrying two negative charges. It is mainly found in the heart of mammals than the rest of the organs.
Cardiolipin is part of the normal plasma lipo-proteins. Traditionally, it was not considered a part of lipoproteins, but recent research has proved otherwise. It is located in the inner membrane of mitochondria, where it participates in the activation of enzymes involved in oxidative phosphyrlation. Cardiolipin is identified as an integral part of the respiratory chain and is part of the crystals of the mitochondrial complex III, IV and the complex ATP-ADP carrier, and is known to be essential for the stability of the protein quaternary structure of the final stage, resulting in ATP production, which is very essential for cellular function.
It is a known fact that cardiolipins play an active role in the mechanisms that regulate oxidative phosphorylation Stage 4 respiratory cycle, returning ejected proton and the entire bacterial and mitochondrial membrane phospholipids, which regulates state 3 respiration by of the relative contributions of proteins that transport protons, electrons and / or metabolites. The barrier properties of phospholipid bilayers supported and regulate the slow leak of protons that is the basis for state 4 respiration. Mitochondrial cardiolipins, especially those with high levels of acyl 18:02 heavily carrier link many proteins and enzymes that are involved in oxidative phosphorylation, some of which contribute to regulating the state 3 respiration. Role in the Parkinson's disease.
Role in Parkinson's disease
Parkinson's disease may be two etiologies-1) Vascular 2) The death or destruction of dopaminergic neurons of the substantia nigra. Cardiolipin is part and increases in HDL cholesterol and the activities of anticoagulation protein plasma S and activated protein C and prevent vascular etiology of Parkinson's in April. The complex is more important than it is destroyed in the Niagra substantia CQ 10 (Co-enzyme Q 10Complex) which is found in mitochondria with cardiolipin. The destruction of CQ10 would be reduced if there is an ample amount of cardiolipin is available. Since forms cardiolipin component of Complex 3:04 Complex, it will be oxidized first CQ10. Mitochondria can replace cardiolipin required for Complex3 and 4 of the Complex of blood. This will delay the apoptosis and delay progression of the disease. Administering CK 10 has side effects as it can be a source of superoxide radicals. In the current case CQ10 with Parkinson's is not a standard combination of treatment.A CQ10 in appropriate doses and similar newly developed cardiolipin could prevent Parkinson's disease in people with a family history of disease and prevent progression in those with the disease. There have been no studies that currently have or accompanied the disease improvement Parkinson's disease after administration CQ10. There is also new evidence that the destruction of cardiolipin in the brain cells as a result of tumors brain.
Role in heart disease
Cardiolipin is found more in the heart. Forming structures with integral the mitochondria of cardiac myocytes, increases the efficiency of the heart as a whole and improves it work. By its anti-coagulant in combination with Protein C and protein S, which would prevent ischemic heart disease. Cardiolipin is beneficial in the maintenance of cardiac myocyte function by ejecting protons through the barrier, facilitating their escape back into the matrix, resulting in the production of ATP, stabilizing the structure of the bilayer phospholiping mitchondria. Any cell it has enough energy (ATP) is able to maintain its function. By having an adequate supply of cardiolipin, heart function will improve and may prevent ischemic heart disease. The future protocol for treatment of disease DIC would include a cardiolipin analogue and CK 10, along with the regular regimen of drugs used for treatment.
Most number of alcoholics that they have dilated cardio myopathy and Wernicke encephalopathy, have DIC and Disease Parkinson's disease. Cardiolipins are byproducts of alcohol metabolism and alcoholics benefit from this protective qualities of cardiolipin.
Future role of Cardiolipn
In recent future, Cardiolipin will be used to treat ischemic heart disease, there has already produced a similar, but was not tried on humans. It will be used in conjunction with CK-10 and Ubiquinine nuerological to treat degenerative diseases including Parkinson's and DIC.
Has this idea was thought of before in medicine?
No, not as a treatment option. People usually focus on HDL cholesterol and associate it the benefit that is at heart. Cardiolipin is the component of HDL, which is responsible for this beneficial role. Giving Cardiolipin directly will be more advantageous than trying to increase the level of HDL. There needs to be more studies that need to be done on the effect of gastric enzymes in Cardiolipin analog, while taking oral and its metablism by the liver. A study conducted by CDC in Cardiolipin effect in mice showed that they more agile, alert and healthier than the part otherwise, without the cardiolipin supplement. They do not look at their benefits and nuerological cardiac benefits.
Cardiolipin can be used in anti-aging therapy in the future. As a cell that has a good supply of ATP is less likely to degenerate to a point where the gene or mechanism of apoptosis will be triggered. The life span of cells in the body increases, leading to overall health and youthfulness. The time it takes to Cardiolipin treatment oriented to enter the mainstream of medicine will be another ten years. But for now, the medical society should recognize that Cardiolipin plays an important role in the future DIC and Parkinson's disease and IHD.
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About the Author
MD, CT(ASCP), Wirral University Teaching Hospital
Dr. Samuel graduated from University of Connecticut in 2003 with a Bachelors in Cyto-technology. He was Board certified by American Society of Clinical Pathology in 2004. He went on to study medicine in Karol Marcinkowski University in Poland and graduated in May of 2009. He sucessfully passed his US Medical Licesing exams. He is currently employed by Wirral University Teaching Hospital in the Foundation year program with future scope to specalize in Histo-Pathology.
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